A common muscle-building supplement, creatine monohydrate, may also have potential benefits for people with depression, according to a new review of previous research. The review examined whether creatine monohydrate could help improve symptoms of major depressive disorder when used alongside established treatments.

Research Findings

Researchers analyzed data from five randomized controlled trials and found some studies showed improvement when creatine was added to other treatments. One trial involving women with depression found those who took 5 grams of creatine daily along with the antidepressant escitalopram experienced greater improvement after eight weeks.

Another study found benefits when creatine was combined with cognitive behavioral therapy. However, the researchers noted that the findings were mixed, with some studies showing no significant improvement. Lead study author Bassam Jeryous Fares said the results show potential but do not provide enough evidence to change medical treatment guidelines.

Scientists have previously found that people with mood disorders may process creatine differently in the brain. Creatine helps the body produce energy, and researchers believe disruptions in the brain’s energy systems may play a role in depression for some people.

Dr. Thea Gallagher, a psychologist and director of wellness programs at NYU Langone, said creatine may have potential because of its role in brain energy production. She noted that creatine has shown a generally safe profile for many healthy adults, but people should talk with a healthcare provider before starting supplements, especially those with kidney disease, pregnancy, or other medical conditions.

Original reporting: WOWO News/Talk (Fort Wayne) — read the source article.