Amy Schumer brought blunt honesty and a few medical updates to a packed Webster Hall audience in New York with podcast host Amanda Hirsch. She talked openly about a recent “botched colonoscopy,” past struggles with weight-loss drugs like Ozempic and WeGovy, and a more positive experience now with Mounjaro and hormone therapy. The comedian mixed the personal with the funny, name-checking perimenopause treatments, telehealth services, and how these changes have affected her energy and sex drive.
Amy Schumer told the crowd in New York that she is in a surprisingly good place these days, starting with a line that cut straight to the point: “I feel happier than I’ve ever been before,” and then gave some context for that feeling. She and Amanda Hirsch were on stage for the “Not Skinny, but Not Fat” podcast event, bringing candid chatter that swung from medical detail to self-deprecating humor. The mood was intimate and direct, the kind of set where a celebrity can drop a clinical update and a punchline back to back.
When Hirsch asked a question about whether her newfound confidence had anything to do with looks, Schumer kept it casual and exact: “Does it have anything to do with being really hot or none of it has to do with being hot,” before pausing and replying, “Oh my God. Thank you so much,” to the audience reaction. Then she turned to a more awkward disclosure: “I actually had kind of a botched colonoscopy, so I’m not feeling very sexual, but see that’s another thing you’re not going to have to worry about for 15 years, OK?” The comment landed with nervous laughter and the realness the crowd came for.
She reassured fans that despite the colonoscopy hiccup, there’s optimism: “You’re going to love it, though.” Schumer has been unusually open about her health journey in recent years, covering weight-loss attempts, side effects, and medical diagnoses. That transparency has become part of her public persona—equal parts brave and blunt—so audiences expect the messy, human stuff along with the jokes.
Schumer also dug into past experiences with injectable weight-loss medications and telehealth options. “I wanted to share and keep it 100 with you, that years ago – and yes, this is completely unsafe to be driving and making a video – years ago, three years ago, I tried WeGovy, and I was like puking,” she admitted, and then continued, “I couldn’t handle it. I don’t know if they’ve changed the formula or whatever … but anyway, I went on this telehealth meeting with MidiHealth, and it was cheap. I wanted to try it myself, cause I wanted to recommend it to my friends who are like nurses and teachers.” That sequence captures how she mixes humor with practical details about health care access and affordability.
The comedian contrasted those rough experiences with a newer routine that seems to suit her better, including hormone therapy. “They put me on estrogen and progesterone because I realized I was in perimenopause and my symptoms of being in perimenopause have disappeared,” Schumer said, noting the immediate improvements she noticed. She described clearer benefits: “My hair is fuller, my skin is better, I have more energy, I want to get down more if you know what I mean – I’m talking about sex.” The candor underscored how hormonal treatment changed daily life for her.
Schumer also gave a thumbs-up to her current weight-loss regimen by name, though not without the characteristic mix of skepticism and relief. “So that’s been great, Mounajro’s been great … I’m having a really good experience with it and I wanted to keep it real with you about that,” she told the crowd, using her platform to compare treatments rather than endorse any single path. Even as she praised results, she kept returning to the practical implications—side effects, tolerability, and whether something fits into a busy life.
The performance threaded pop-culture references and career nods alongside the medical talk, mentioning projects like Kinda Pregnant and the Trainwreck era that fans still associate with her. Schumer’s representatives did not immediately respond to a request for comment, which left the rest of the conversation to her own stage anecdotes and the occasional clinical detail. For a celebrity willing to blend standup and health updates, the New York appearance read like a check-in from someone navigating middle age, medicine, and a public career on her own terms.
