Researchers at Yale University have solved a centuries-old mystery involving one of Italy’s most famous families. Grand Duke Francesco I de’ Medici, the Renaissance ruler of Tuscany, died suddenly in 1587. His wife, Bianca Cappello, died a day apart after falling ill with intermittent fevers following a stay at a mosquito-filled villa.
The Mystery Solved
Working with paleopathologists from the University of Pisa in Italy, the team analyzed DNA extracted from the ribs of Francesco I de’ Medici, as well as Giovanni de’ Medici, his younger brother who died of malaria 25 years earlier. The research was led by Serena Tucci, assistant professor of anthropology at Yale University.
Researchers found genetic traces of Plasmodium falciparum, the parasite responsible for the deadliest form of malaria — effectively debunking the longstanding poisoning theory. The team also discovered molecular traces of P. falciparum and a second species, P. malariae, in the remains of Francesco de Medici.
The results are scientific proof to dispel persistent speculation that Francesco de Medici was poisoned to death. Archival sources, including contemporary reports from court physicians, describe the symptoms the brothers suffered that are consistent with malaria, which was called ‘febbre terzana’ by residents of Central Italy at the time.
Original reporting: Fox News (HLL/CB) — read the source article.
